Infections in Patients with Inherited Defects in Phagocytic Function

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Infections in patients with inherited defects in phagocytic function.

Patients with defects in phagocytic function are predisposed to intracellular microorganisms and typically have early dissemination of the infection. Recognition of the underlying disorder and aggressive antimicrobial therapy has been beneficial for the patients. Improved understanding of the pathophysiology has also affected patient management by allowing specific, targeted immunomodulatory in...

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Effect of cefodizime and ceftriaxone on phagocytic function in patients with severe infections.

Thirty patients with severe bacterial infections were treated with 50 mg of cefodizime per kg of body weight once daily or 50 mg of ceftriaxone per kg once daily for 10 +/- 3 days. The effect of cefodizime and ceftriaxone on the phagocytic capacity and generation of reactive oxygen intermediates after phagocytosis by granulocytes was assessed prior to, during, and after therapy. Flow cytometry ...

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ژورنال

عنوان ژورنال: Clinical Microbiology Reviews

سال: 2003

ISSN: 0893-8512,1098-6618

DOI: 10.1128/cmr.16.4.597-621.2003